6QBI

NMR structure of BB_P28, Borrelia burgdorferi outer surface lipoprotein

6QBI の概要

• エントリーDOI: 10.2210/pdb6qbi/pdb
• NMR情報: BMRB: 34344
• 分子名称: Surface protein, mlp lipoprotein family (1 entity in total)
• 機能のキーワード: lipoprotein, membrane protein
• 由来する生物種: Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11038.11

構造登録者

Fridmanis, J.,Otikovs, M.,Brangulis, K.,Jaudzems, K. (登録日: 2018-12-21, 公開日: 2020-01-29, 最終更新日: 2024-11-06)

主引用文献

Fridmanis, J.,Otikovs, M.,Brangulis, K.,Tars, K.,Jaudzems, K.
Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family.
Proteins, 2020

PubMed Abstract: Lyme disease is the most widespread vector-transmitted disease in North America and Europe, caused by infection with Borrelia burgdorferi sensu lato complex spirochetes. We report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBP28, a member of the multicopy lipoprotein (mlp) family. The structure comprises a tether peptide, five α-helices and an extended C-terminal loop. The fold is similar to that of Borrelia turicatae outer surface protein BTA121, which is known to bind lipids. These results contribute to the understanding of Lyme disease pathogenesis by revealing the molecular structure of a protein from the widely found mlp family.

PubMed: 32949018
DOI: 10.1002/prot.26011

実験手法

SOLUTION NMR