6QA8

Glycogen Phosphorylase b in complex with 28

Summary for 6QA8

• Entry DOI: 10.2210/pdb6qa8/pdb
• Descriptor: Glycogen phosphorylase, muscle form, (5~{S},7~{R},8~{S},9~{S},10~{R})-7-(hydroxymethyl)-8,9,10-tris(oxidanyl)-2-phenyl-6-oxa-1,3-diazaspiro[4.5]dec-1-en-4-one, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97977.83

Authors

Kyriakis, E.,Stravodimos, G.A.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2018-12-18, release date: 2019-06-26, Last modification date: 2019-07-24)

• Primary citation: Szabo, K.E.,Kyriakis, E.,Psarra, A.G.,Karra, A.G.,Sipos, A.,Docsa, T.,Stravodimos, G.A.,Katsidou, E.,Skamnaki, V.T.,Liggri, P.G.V.,Zographos, S.E.,Mandi, A.,Kiraly, S.B.,Kurtan, T.,Leonidas, D.D.,Somsak, L.; Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.; J.Med.Chem., 62:6116-6136, 2019; PubMed: 31251604; DOI: 10.1021/acs.jmedchem.9b00356

Experimental method

X-RAY DIFFRACTION (2.35 Å)