6Q81

Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state

Summary for 6Q81

• Entry DOI: 10.2210/pdb6q81/pdb
• EMDB information: 4391
• Descriptor: P-glycoprotein (ABCB1), ADENOSINE-5'-DIPHOSPHATE (2 entities in total)
• Functional Keywords: p-glycoprotein; abcb1; atp-binding cassette; transporter; membrane protein; protein structure, membrane protein
• Biological source: Mus musculus
• Total number of polymer chains: 1
• Total formula weight: 141661.17

Authors

Ford, R.C.,Thonghin, N.,Collins, R.F.,Barbieri, A.,Shafi, T.,Siebert, A. (deposition date: 2018-12-13, release date: 2018-12-26, Last modification date: 2024-05-15)

Primary citation

Thonghin, N.,Collins, R.F.,Barbieri, A.,Shafi, T.,Siebert, A.,Ford, R.C.
Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution.
Bmc Struct.Biol., 18:17-17, 2018

PubMed Abstract: P-glycoprotein (ABCB1) is an ATP-binding cassette transporter that plays an important role in the clearance of drugs and xenobiotics and is associated with multi-drug resistance in cancer. Although several P-glycoprotein structures are available, these are either at low resolution, or represent mutated and/or quiescent states of the protein.

PubMed: 30545335
DOI: 10.1186/s12900-018-0098-z

Experimental method

ELECTRON MICROSCOPY (7.9 Å)