6Q7B

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATDL09

Summary for 6Q7B

• Entry DOI: 10.2210/pdb6q7b/pdb
• Descriptor: Ephrin type-A receptor 2, 3-[[4-imidazol-1-yl-6-[(3~{S})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
• Functional Keywords: inhibitor, complex, protein tyrosine kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34987.34

Authors

Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Gande, S.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-12-13, release date: 2020-01-15, Last modification date: 2024-01-24)

• Primary citation: Troester, A.,Kudlinzki, D.,Saxena, K.,Gande, S.,Schwalbe, H.; Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.009 Å)