6Q6N
Crystal structure of recombinant human beta-glucocerebrosidase in complex with biphenyl-cyclophellitol inhibitor (ME655)
Summary for 6Q6N
| Entry DOI | 10.2210/pdb6q6n/pdb |
| Related | 6Q6K 6Q6L |
| Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (7 entities in total) |
| Functional Keywords | hydrolase, retaining beta-glucosidase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 116117.34 |
| Authors | Rowland, R.J.,Davies, G.J. (deposition date: 2018-12-11, release date: 2019-03-27, Last modification date: 2024-01-24) |
| Primary citation | Artola, M.,Kuo, C.L.,Lelieveld, L.T.,Rowland, R.J.,van der Marel, G.A.,Codee, J.D.C.,Boot, R.G.,Davies, G.J.,Aerts, J.M.F.G.,Overkleeft, H.S. Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J.Am.Chem.Soc., 141:4214-4218, 2019 Cited by PubMed: 30811188DOI: 10.1021/jacs.9b00056 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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