6Q6L
Crystal structure of recombinant human beta-glucocerebrosidase in complex with adamantyl-cyclophellitol inhibitor (ME656)
Summary for 6Q6L
Entry DOI | 10.2210/pdb6q6l/pdb |
Related | 6Q6K |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | hydrolase, retaining beta-glucosidase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116625.85 |
Authors | Rowland, R.J.,Davies, G.J. (deposition date: 2018-12-11, release date: 2019-03-27, Last modification date: 2024-01-24) |
Primary citation | Artola, M.,Kuo, C.L.,Lelieveld, L.T.,Rowland, R.J.,van der Marel, G.A.,Codee, J.D.C.,Boot, R.G.,Davies, G.J.,Aerts, J.M.F.G.,Overkleeft, H.S. Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J.Am.Chem.Soc., 141:4214-4218, 2019 Cited by PubMed: 30811188DOI: 10.1021/jacs.9b00056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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