6Q6L

Crystal structure of recombinant human beta-glucocerebrosidase in complex with adamantyl-cyclophellitol inhibitor (ME656)

6Q6L の概要

• エントリーDOI: 10.2210/pdb6q6l/pdb
• 関連するPDBエントリー: 6Q6K
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: hydrolase, retaining beta-glucosidase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116625.85

構造登録者

Rowland, R.J.,Davies, G.J. (登録日: 2018-12-11, 公開日: 2019-03-27, 最終更新日: 2024-01-24)

• 主引用文献: Artola, M.,Kuo, C.L.,Lelieveld, L.T.,Rowland, R.J.,van der Marel, G.A.,Codee, J.D.C.,Boot, R.G.,Davies, G.J.,Aerts, J.M.F.G.,Overkleeft, H.S.; Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.; J.Am.Chem.Soc., 141:4214-4218, 2019; PubMed: 30811188; DOI: 10.1021/jacs.9b00056

実験手法

X-RAY DIFFRACTION (1.81 Å)