6Q68

Crystal structure of bovine ACBD3 GOLD domain in complex with 3A protein of enterovirus-F2 (fusion protein)

6Q68 の概要

• エントリーDOI: 10.2210/pdb6q68/pdb
• 分子名称: Acyl-CoA binding domain containing 3, Genome polyprotein, beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: complex, enterovirus, picornavirus, viral protein
• 由来する生物種: Bos taurus (Bovine); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 49872.91

構造登録者

Smola, M.,Boura, E.,Klima, M. (登録日: 2018-12-10, 公開日: 2019-11-13, 最終更新日: 2024-01-24)

主引用文献

Smola, M.,Horova, V.,Boura, E.,Klima, M.
Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses.
Arch. Virol., 165:355-366, 2020

PubMed Abstract: Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members of the genera Enterovirus and Kobuvirus. While the human-infecting enteroviruses and kobuviruses have been intensively studied during the past decades in great detail, research on livestock-infecting viruses has been mostly limited to the genomic characterization of the viral strains identified worldwide. Here, we extend our previous studies of the structure and function of the complexes composed of the non-structural 3A proteins of human-infecting enteroviruses and kobuviruses and the host ACBD3 protein and present a structural and functional characterization of the complexes of the following livestock-infecting picornaviruses: bovine enteroviruses EV-E and EV-F, porcine enterovirus EV-G, and porcine kobuvirus AiV-C. We present a series of crystal structures of these complexes and demonstrate the role of these complexes in facilitation of viral replication.

PubMed: 31845156
DOI: 10.1007/s00705-019-04490-9

実験手法

X-RAY DIFFRACTION (3.161 Å)