6Q49

CDK2 in complex with FragLite6

6Q49 の概要

• エントリーDOI: 10.2210/pdb6q49/pdb
• 分子名称: Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE, 4-bromanyl-1~{H}-pyridin-2-one, ... (4 entities in total)
• 機能のキーワード: fragment, fraglite, cdk2, inhibitor, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35013.48

構造登録者

Wood, D.J.,Martin, M.P.,Noble, M.E.M. (登録日: 2018-12-05, 公開日: 2019-03-20, 最終更新日: 2024-01-24)

• 主引用文献: Wood, D.J.,Lopez-Fernandez, J.D.,Knight, L.E.,Al-Khawaldeh, I.,Gai, C.,Lin, S.,Martin, M.P.,Miller, D.C.,Cano, C.,Endicott, J.A.,Hardcastle, I.R.,Noble, M.E.M.,Waring, M.J.; FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.; J.Med.Chem., 62:3741-3752, 2019; PubMed: 30860382; DOI: 10.1021/acs.jmedchem.9b00304

実験手法

X-RAY DIFFRACTION (1 Å)