6Q0Q

Crystal structure of Human galectin-3 CRD in complex with Methyl 3-O-(1-{3-O-[1-(b-D-galactopyranosyl)-1,2,3-triazol-4-yl]-methyl-b-D-galactopyranosyl}-1,2,3-triazol-4-yl)-methyl-b-D-galactopyranoside

6Q0Q の概要

• エントリーDOI: 10.2210/pdb6q0q/pdb
• 分子名称: Galectin-3, CHLORIDE ION, (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[4-[[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[4-[[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-methoxy-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]-1,2,3-triazol-1-yl]-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]-1,2,3-triazol-1-yl]oxane-3,4,5-triol, ... (4 entities in total)
• 機能のキーワード: sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16474.17

構造登録者

Kishor, C.,Blanchard, H. (登録日: 2019-08-02, 公開日: 2020-04-29, 最終更新日: 2024-03-13)

• 主引用文献: Dussouy, C.,Kishor, C.,Lambert, A.,Lamoureux, C.,Blanchard, H.,Grandjean, C.; Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development.; Chem.Biol.Drug Des., 96:1123-1133, 2020; PubMed: 32220037; DOI: 10.1111/cbdd.13683

実験手法

X-RAY DIFFRACTION (1.98601176315 Å)