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6PZA

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide

Summary for 6PZA
Entry DOI10.2210/pdb6pza/pdb
EMDB information20530
DescriptorATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... (4 entities in total)
Functional Keywordskatp, sur1, gbc, membrane protein
Biological sourceCricetus cricetus (Black-bellied hamster)
More
Total number of polymer chains2
Total formula weight221980.48
Authors
Shyng, S.L.,Yoshioka, C.,Martin, G.M.,Sung, M.W. (deposition date: 2019-07-31, release date: 2019-08-14, Last modification date: 2020-10-07)
Primary citationMartin, G.M.,Sung, M.W.,Yang, Z.,Innes, L.M.,Kandasamy, B.,David, L.L.,Yoshioka, C.,Shyng, S.L.
Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8:-, 2019
Cited by
PubMed: 31343405
DOI: 10.7554/eLife.46417
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.74 Å)
Structure validation

222036

건을2024-07-03부터공개중

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