6PZA

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide

6PZA の概要

• エントリーDOI: 10.2210/pdb6pza/pdb
• EMDBエントリー: 20530
• 分子名称: ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... (4 entities in total)
• 機能のキーワード: katp, sur1, gbc, membrane protein
• 由来する生物種: Cricetus cricetus (Black-bellied hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 221980.48

構造登録者

Shyng, S.L.,Yoshioka, C.,Martin, G.M.,Sung, M.W. (登録日: 2019-07-31, 公開日: 2019-08-14, 最終更新日: 2020-10-07)

• 主引用文献: Martin, G.M.,Sung, M.W.,Yang, Z.,Innes, L.M.,Kandasamy, B.,David, L.L.,Yoshioka, C.,Shyng, S.L.; Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.; Elife, 8:-, 2019; PubMed: 31343405; DOI: 10.7554/eLife.46417

実験手法

ELECTRON MICROSCOPY (3.74 Å)