6PYC

Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin

Summary for 6PYC

• Entry DOI: 10.2210/pdb6pyc/pdb
• Descriptor: KoH body Fab heavy chain, KoH body Fab light chain, anti-kappa antibody Fab heavy chain, ... (6 entities in total)
• Functional Keywords: marinobufagenin, antibody engineering, bence-jones dimer, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 4
• Total formula weight: 95405.72

Authors

Franklin, M.C.,Macdonald, L.E.,McWhirter, J.,Murphy, A.J. (deposition date: 2019-07-29, release date: 2019-12-25, Last modification date: 2023-10-11)

• Primary citation: Macdonald, L.E.,Meagher, K.A.,Franklin, M.C.,Levenkova, N.,Hansen, J.,Badithe, A.T.,Zhong, M.,Krueger, P.,Rafique, A.,Tu, N.,Shevchuk, J.,Wadhwa, S.,Ehrlich, G.,Bautista, J.,Grant, C.,Esau, L.,Poueymirou, W.T.,Auerbach, W.,Morton, L.,Babb, R.,Chen, G.,Huang, T.,MacDonald, D.,Graham, K.,Gurer, C.,Voronina, V.A.,McWhirter, J.R.,Guo, C.,Yancopoulos, G.D.,Murphy, A.J.; Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.; Proc.Natl.Acad.Sci.USA, 117:292-299, 2020; PubMed: 31879340; DOI: 10.1073/pnas.1901734117

Experimental method

X-RAY DIFFRACTION (3.6 Å)