6PYC

Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin

6PYC の概要

• エントリーDOI: 10.2210/pdb6pyc/pdb
• 分子名称: KoH body Fab heavy chain, KoH body Fab light chain, anti-kappa antibody Fab heavy chain, ... (6 entities in total)
• 機能のキーワード: marinobufagenin, antibody engineering, bence-jones dimer, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95405.72

構造登録者

Franklin, M.C.,Macdonald, L.E.,McWhirter, J.,Murphy, A.J. (登録日: 2019-07-29, 公開日: 2019-12-25, 最終更新日: 2023-10-11)

• 主引用文献: Macdonald, L.E.,Meagher, K.A.,Franklin, M.C.,Levenkova, N.,Hansen, J.,Badithe, A.T.,Zhong, M.,Krueger, P.,Rafique, A.,Tu, N.,Shevchuk, J.,Wadhwa, S.,Ehrlich, G.,Bautista, J.,Grant, C.,Esau, L.,Poueymirou, W.T.,Auerbach, W.,Morton, L.,Babb, R.,Chen, G.,Huang, T.,MacDonald, D.,Graham, K.,Gurer, C.,Voronina, V.A.,McWhirter, J.R.,Guo, C.,Yancopoulos, G.D.,Murphy, A.J.; Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.; Proc.Natl.Acad.Sci.USA, 117:292-299, 2020; PubMed: 31879340; DOI: 10.1073/pnas.1901734117

実験手法

X-RAY DIFFRACTION (3.6 Å)