6PWL

ADC-7 in complex with boronic acid transition state inhibitor LP06

Summary for 6PWL

Entry DOI	10.2210/pdb6pwl/pdb
Descriptor	Beta-lactamase, (7Z)-7-(2-amino-1,3-thiazol-4-yl)-1,1,3-trihydroxy-10,10-dimethyl-1,6-dioxo-2,9-dioxa-5,8-diaza-1lambda~5~-phospha-3-boraundec-7-en-11-oic acid, GLYCINE, ... (4 entities in total)
Functional Keywords	inhibitor, beta-lactamase, batsi, adc-7., hydrolase
Biological source	Acinetobacter baumannii
Total number of polymer chains	4
Total formula weight	164949.47
Authors	Curtis, B.C.,Powers, R.A.,Wallar, B.J. (deposition date: 2019-07-23, release date: 2020-10-21, Last modification date: 2023-10-11)
Primary citation	Curtis, B.N.,Smolen, K.A.,Barlow, S.J.,Caselli, E.,Prati, F.,Taracila, M.A.,Bonomo, R.A.,Wallar, B.J.,Powers, R.A. Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog. Antimicrob.Agents Chemother., 64:-, 2020 Cited by PubMed: 32988830 DOI: 10.1128/AAC.01183-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation