6PWL

ADC-7 in complex with boronic acid transition state inhibitor LP06

6PWL の概要

• エントリーDOI: 10.2210/pdb6pwl/pdb
• 分子名称: Beta-lactamase, (7Z)-7-(2-amino-1,3-thiazol-4-yl)-1,1,3-trihydroxy-10,10-dimethyl-1,6-dioxo-2,9-dioxa-5,8-diaza-1lambda~5~-phospha-3-boraundec-7-en-11-oic acid, GLYCINE, ... (4 entities in total)
• 機能のキーワード: inhibitor, beta-lactamase, batsi, adc-7., hydrolase
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 164949.47

構造登録者

Curtis, B.C.,Powers, R.A.,Wallar, B.J. (登録日: 2019-07-23, 公開日: 2020-10-21, 最終更新日: 2023-10-11)

• 主引用文献: Curtis, B.N.,Smolen, K.A.,Barlow, S.J.,Caselli, E.,Prati, F.,Taracila, M.A.,Bonomo, R.A.,Wallar, B.J.,Powers, R.A.; Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.; Antimicrob.Agents Chemother., 64:-, 2020; PubMed: 32988830; DOI: 10.1128/AAC.01183-20

実験手法

X-RAY DIFFRACTION (1.67 Å)