6PSC
Antibody scFv-M204 trimeric state
Summary for 6PSC
Entry DOI | 10.2210/pdb6psc/pdb |
Descriptor | scFv-M204 antibody (1 entity in total) |
Functional Keywords | anti-tau-oligomer scfv antibody, immune system |
Biological source | Oryctolagus cuniculus |
Total number of polymer chains | 3 |
Total formula weight | 81185.87 |
Authors | Abskharon, R.,Sawaya, M.R.,Seidler, P.M.,Cascio, D.,Eisenberg, D.S. (deposition date: 2019-07-12, release date: 2020-06-17, Last modification date: 2023-10-11) |
Primary citation | Abskharon, R.,Seidler, P.M.,Sawaya, M.R.,Cascio, D.,Yang, T.P.,Philipp, S.,Williams, C.K.,Newell, K.L.,Ghetti, B.,DeTure, M.A.,Dickson, D.W.,Vinters, H.V.,Felgner, P.L.,Nakajima, R.,Glabe, C.G.,Eisenberg, D.S. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295:10662-10676, 2020 Cited by PubMed: 32493775DOI: 10.1074/jbc.RA120.013638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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