6PS4

XFEL beta2 AR structure by ligand exchange from Timolol to ICI-118551.

6PS4 の概要

• エントリーDOI: 10.2210/pdb6ps4/pdb
• 分子名称: Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: gpcr, complex-lcp method, sbdd, drug design, xfel, lcp-sfx, ligand exchange, timolol, ici-118551. b2ar, beta2ar, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63421.74

構造登録者

Ishchenko, A.,Stauch, B.,Han, G.W.,Batyuk, A.,Shiriaeva, A.,Li, C.,Zatsepin, N.A.,Weierstall, U.,Liu, W.,Nango, E.,Nakane, T.,Tanaka, R.,Tono, K.,Joti, Y.,Iwata, S.,Moraes, I.,Gati, C.,Cherezov, C. (登録日: 2019-07-12, 公開日: 2019-11-13, 最終更新日: 2023-10-11)

• 主引用文献: Ishchenko, A.,Stauch, B.,Han, G.W.,Batyuk, A.,Shiriaeva, A.,Li, C.,Zatsepin, N.,Weierstall, U.,Liu, W.,Nango, E.,Nakane, T.,Tanaka, R.,Tono, K.,Joti, Y.,Iwata, S.,Moraes, I.,Gati, C.,Cherezov, V.; Toward G protein-coupled receptor structure-based drug design using X-ray lasers.; Iucrj, 6:1106-1119, 2019; PubMed: 31709066; DOI: 10.1107/S2052252519013137

実験手法

X-RAY DIFFRACTION (2.6 Å)