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6PS3

XFEL beta2 AR structure by ligand exchange from Timolol to Carvedilol.

Summary for 6PS3
Entry DOI10.2210/pdb6ps3/pdb
DescriptorFusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, SULFATE ION, ... (7 entities in total)
Functional Keywordsgpcr, complex-lcp method, sbdd, drug design, xfel, lcp-sfx, ligand exchange, timolol, cavedilol, b2ar, beta2ar, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight62220.71
Authors
Primary citationIshchenko, A.,Stauch, B.,Han, G.W.,Batyuk, A.,Shiriaeva, A.,Li, C.,Zatsepin, N.,Weierstall, U.,Liu, W.,Nango, E.,Nakane, T.,Tanaka, R.,Tono, K.,Joti, Y.,Iwata, S.,Moraes, I.,Gati, C.,Cherezov, V.
Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6:1106-1119, 2019
Cited by
PubMed: 31709066
DOI: 10.1107/S2052252519013137
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

数据于2024-03-27公开中

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