6PRB
S. aureus dihydrofolate reductase co-crystallized with cyclopropyl-dimethyoxydihydropthalazine inhibitor and NADP(H)
6PRB の概要
エントリーDOI | 10.2210/pdb6prb/pdb |
分子名称 | Dihydrofolate reductase, (2E)-1-[(1S)-1-cyclopropyl-6,7-dimethoxy-3,4-dihydrophthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one, (2E)-1-[(1R)-1-cyclopropyl-6,7-dimethoxyphthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one, ... (6 entities in total) |
機能のキーワード | dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
由来する生物種 | Staphylococcus aureus |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 20536.04 |
構造登録者 | |
主引用文献 | Muddala, N.P.,White, J.C.,Nammalwar, B.,Pratt, I.,Thomas, L.M.,Bunce, R.A.,Berlin, K.D.,Bourne, C.R. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200:112412-112412, 2020 Cited by PubMed: 32502861DOI: 10.1016/j.ejmech.2020.112412 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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