6PR8
S. aureus dihydrofoate reductase co-crystallized with 3,5-dimethylphenyl-dihydropthalazine inhibitor and NADP(H)
6PR8 の概要
エントリーDOI | 10.2210/pdb6pr8/pdb |
分子名称 | Dihydrofolate reductase, (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(3,5-dimethylphenyl)phthalazin-2(1H)-yl]prop-2-en-1-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
機能のキーワード | dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
由来する生物種 | Staphylococcus aureus |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 20087.56 |
構造登録者 | |
主引用文献 | Muddala, N.P.,White, J.C.,Nammalwar, B.,Pratt, I.,Thomas, L.M.,Bunce, R.A.,Berlin, K.D.,Bourne, C.R. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200:112412-112412, 2020 Cited by PubMed: 32502861DOI: 10.1016/j.ejmech.2020.112412 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.01 Å) |
構造検証レポート
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