6PPY

Crystal structure of NeuNAc oxime complexed with NeuB, an N-acetylneuraminate synthase from Neisseria meningitidis

6PPY の概要

• エントリーDOI: 10.2210/pdb6ppy/pdb
• 分子名称: N-acetylneuraminate synthase, (2E,4S,5R,6R,7S,8R)-5-(acetylamino)-4,6,7,8,9-pentahydroxy-2-(hydroxyimino)nonanoic acid (non-preferred name) (3 entities in total)
• 機能のキーワード: neub, sialic acid synthase, inhibitor complex, n-acetyl-neuraminate synthase, neunac oxime, transferase, biosynthetic protein
• 由来する生物種: Neisseria meningitidis serogroup B
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38720.02

構造登録者

Rosanally, A.Z.,Junop, M.J.,Berti, P.J. (登録日: 2019-07-08, 公開日: 2019-10-02, 最終更新日: 2023-10-11)

• 主引用文献: Popovic, V.,Morrison, E.,Rosanally, A.Z.,Balachandran, N.,Senson, A.W.,Szabla, R.,Junop, M.S.,Berti, P.J.; NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB.; Biochemistry, 58:4236-4245, 2019; PubMed: 31549502; DOI: 10.1021/acs.biochem.9b00654

実験手法

X-RAY DIFFRACTION (2 Å)