6PNO
Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-isopropylsulfamoyl)phenyl)acetamide
Summary for 6PNO
Entry DOI | 10.2210/pdb6pno/pdb |
Descriptor | Glutathione S-transferase omega-1, 2-chloro-N-{4-chloro-3-[(propan-2-yl)sulfamoyl]phenyl}acetamide, L(+)-TARTARIC ACID, ... (5 entities in total) |
Functional Keywords | glutathione transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 28232.13 |
Authors | Oakley, A.J. (deposition date: 2019-07-02, release date: 2019-07-24, Last modification date: 2023-10-11) |
Primary citation | Xie, Y.,Tummala, P.,Oakley, A.J.,Deora, G.S.,Nakano, Y.,Rooke, M.,Cuellar, M.E.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Casarotto, M.G.,Board, P.G.,Baell, J.B. Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors. J.Med.Chem., 63:2894-2914, 2020 Cited by PubMed: 32105470DOI: 10.1021/acs.jmedchem.9b01391 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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