6PNO

Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-isopropylsulfamoyl)phenyl)acetamide

6PNO の概要

• エントリーDOI: 10.2210/pdb6pno/pdb
• 分子名称: Glutathione S-transferase omega-1, 2-chloro-N-{4-chloro-3-[(propan-2-yl)sulfamoyl]phenyl}acetamide, L(+)-TARTARIC ACID, ... (5 entities in total)
• 機能のキーワード: glutathione transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28232.13

構造登録者

Oakley, A.J. (登録日: 2019-07-02, 公開日: 2019-07-24, 最終更新日: 2023-10-11)

• 主引用文献: Xie, Y.,Tummala, P.,Oakley, A.J.,Deora, G.S.,Nakano, Y.,Rooke, M.,Cuellar, M.E.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Casarotto, M.G.,Board, P.G.,Baell, J.B.; Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors.; J.Med.Chem., 63:2894-2914, 2020; PubMed: 32105470; DOI: 10.1021/acs.jmedchem.9b01391

実験手法

X-RAY DIFFRACTION (1.82 Å)