6PMX

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(3-(2-Aminoethyl)phenyl)-4-methylquinolin-2-amine

6PMX の概要

• エントリーDOI: 10.2210/pdb6pmx/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100050.69

構造登録者

Li, H.,Poulos, T.L. (登録日: 2019-07-02, 公開日: 2020-04-29, 最終更新日: 2023-10-11)

• 主引用文献: Cinelli, M.A.,Reidl, C.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.; First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.; J.Med.Chem., 63:4528-4554, 2020; PubMed: 32302123; DOI: 10.1021/acs.jmedchem.9b01573

実験手法

X-RAY DIFFRACTION (2.05 Å)