6PJ1

Crystal structure of HCV NS3/4A D168A protease in complex with P4-4(AJ-74)

Summary for 6PJ1

Entry DOI	10.2210/pdb6pj1/pdb
Descriptor	NS3/4A protease, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase/hydrolase inhibitor
Biological source	Hepacivirus C
Total number of polymer chains	1
Total formula weight	24677.24
Authors	Zephyr, J.,Schiffer, C.A. (deposition date: 2019-06-27, release date: 2020-03-04, Last modification date: 2023-10-11)
Primary citation	Matthew, A.N.,Zephyr, J.,Nageswara Rao, D.,Henes, M.,Kamran, W.,Kosovrasti, K.,Hedger, A.K.,Lockbaum, G.J.,Timm, J.,Ali, A.,Kurt Yilmaz, N.,Schiffer, C.A. Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. Mbio, 11:-, 2020 Cited by PubMed: 32234812 DOI: 10.1128/mBio.00172-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation