6PFK

PHOSPHOFRUCTOKINASE, INHIBITED T-STATE

「5PFK」から置き換えられました

6PFK の概要

• エントリーDOI: 10.2210/pdb6pfk/pdb
• 分子名称: PHOSPHOFRUCTOKINASE, 2-PHOSPHOGLYCOLIC ACID (3 entities in total)
• 機能のキーワード: transferase, kinase, glycolysis
• 由来する生物種: Geobacillus stearothermophilus
• 細胞内の位置: Cytoplasm: P00512
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 137295.53

構造登録者

Evans, P.R.,Schirmer, T.,Auer, M. (登録日: 1996-01-04, 公開日: 1996-07-11, 最終更新日: 2024-03-13)

主引用文献

Schirmer, T.,Evans, P.R.
Structural basis of the allosteric behaviour of phosphofructokinase.
Nature, 343:140-145, 1990

PubMed Abstract: Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.

PubMed: 2136935
DOI: 10.1038/343140a0

実験手法

X-RAY DIFFRACTION (2.6 Å)