6PFH
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-cyanophenyl)acetic acid.
Summary for 6PFH
Entry DOI | 10.2210/pdb6pfh/pdb |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | inhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Cryptosporidium hominis |
Total number of polymer chains | 5 |
Total formula weight | 311154.89 |
Authors | Czyzyk, D.C.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2019-06-21, release date: 2019-10-02, Last modification date: 2023-10-11) |
Primary citation | Czyzyk, D.J.,Valhondo, M.,Deiana, L.,Tirado-Rives, J.,Jorgensen, W.L.,Anderson, K.S. Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183:111673-111673, 2019 Cited by PubMed: 31536894DOI: 10.1016/j.ejmech.2019.111673 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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