6PDG

Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83

Summary for 6PDG

Entry DOI	10.2210/pdb6pdg/pdb
Descriptor	Histone acetyltransferase KAT8, ZINC ION, SODIUM ION, ... (7 entities in total)
Functional Keywords	inhibitor, complex, myst, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32712.88
Authors	Hermans, S.J.,Parker, M.W.,Thomas, T.,Baell, J.B. (deposition date: 2019-06-18, release date: 2020-04-01, Last modification date: 2023-11-15)
Primary citation	Priebbenow, D.L.,Leaver, D.J.,Nguyen, N.,Cleary, B.,Lagiakos, H.R.,Sanchez, J.,Xue, L.,Huang, F.,Sun, Y.,Mujumdar, P.,Mudududdla, R.,Varghese, S.,Teguh, S.,Charman, S.A.,White, K.L.,Shackleford, D.M.,Katneni, K.,Cuellar, M.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Street, I.P.,Monahan, B.J.,Jarman, K.E.,Jousset Sabroux, H.,Falk, H.,Chung, M.C.,Hermans, S.J.,Downer, N.L.,Parker, M.W.,Voss, A.K.,Thomas, T.,Baell, J.B. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63:4655-4684, 2020 Cited by PubMed: 32118427 DOI: 10.1021/acs.jmedchem.9b02071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.919 Å)

Structure validation