6PDG

Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83

6PDG の概要

• エントリーDOI: 10.2210/pdb6pdg/pdb
• 分子名称: Histone acetyltransferase KAT8, ZINC ION, SODIUM ION, ... (7 entities in total)
• 機能のキーワード: inhibitor, complex, myst, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32712.88

構造登録者

Hermans, S.J.,Parker, M.W.,Thomas, T.,Baell, J.B. (登録日: 2019-06-18, 公開日: 2020-04-01, 最終更新日: 2023-11-15)

• 主引用文献: Priebbenow, D.L.,Leaver, D.J.,Nguyen, N.,Cleary, B.,Lagiakos, H.R.,Sanchez, J.,Xue, L.,Huang, F.,Sun, Y.,Mujumdar, P.,Mudududdla, R.,Varghese, S.,Teguh, S.,Charman, S.A.,White, K.L.,Shackleford, D.M.,Katneni, K.,Cuellar, M.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Street, I.P.,Monahan, B.J.,Jarman, K.E.,Jousset Sabroux, H.,Falk, H.,Chung, M.C.,Hermans, S.J.,Downer, N.L.,Parker, M.W.,Voss, A.K.,Thomas, T.,Baell, J.B.; Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.; J.Med.Chem., 63:4655-4684, 2020; PubMed: 32118427; DOI: 10.1021/acs.jmedchem.9b02071

実験手法

X-RAY DIFFRACTION (1.919 Å)