6PCK
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7
Summary for 6PCK
Entry DOI | 10.2210/pdb6pck/pdb |
Descriptor | Diphosphoinositol polyphosphate phosphohydrolase 1, (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | inositol pyrophosphate, inositol phosphate, kinase, phosphatase, ppip5k, cell polarity, osmotic response, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17950.59 |
Authors | Dollins, D.E.,Neubauer, J.,Dong, J.,York, J.D. (deposition date: 2019-06-17, release date: 2020-04-29, Last modification date: 2023-10-11) |
Primary citation | Dollins, D.E.,Bai, W.,Fridy, P.C.,Otto, J.C.,Neubauer, J.L.,Gattis, S.G.,Mehta, K.P.M.,York, J.D. Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117:9356-9364, 2020 Cited by PubMed: 32303658DOI: 10.1073/pnas.1908875117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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