6PCK

Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7

6PCK の概要

• エントリーDOI: 10.2210/pdb6pck/pdb
• 分子名称: Diphosphoinositol polyphosphate phosphohydrolase 1, (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: inositol pyrophosphate, inositol phosphate, kinase, phosphatase, ppip5k, cell polarity, osmotic response, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17950.59

構造登録者

Dollins, D.E.,Neubauer, J.,Dong, J.,York, J.D. (登録日: 2019-06-17, 公開日: 2020-04-29, 最終更新日: 2023-10-11)

• 主引用文献: Dollins, D.E.,Bai, W.,Fridy, P.C.,Otto, J.C.,Neubauer, J.L.,Gattis, S.G.,Mehta, K.P.M.,York, J.D.; Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.; Proc.Natl.Acad.Sci.USA, 117:9356-9364, 2020; PubMed: 32303658; DOI: 10.1073/pnas.1908875117

実験手法

X-RAY DIFFRACTION (1.2 Å)