6P9R
E.coli LpxA in complex with UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc and Compound 6
Summary for 6P9R
Entry DOI | 10.2210/pdb6p9r/pdb |
Descriptor | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | acyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 30584.35 |
Authors | Ma, X.,Shia, S.,Ornelas, E. (deposition date: 2019-06-10, release date: 2020-03-11, Last modification date: 2023-10-11) |
Primary citation | Han, W.,Ma, X.,Balibar, C.J.,Baxter Rath, C.M.,Benton, B.,Bermingham, A.,Casey, F.,Chie-Leon, B.,Cho, M.K.,Frank, A.O.,Frommlet, A.,Ho, C.M.,Lee, P.S.,Li, M.,Lingel, A.,Ma, S.,Merritt, H.,Ornelas, E.,De Pascale, G.,Prathapam, R.,Prosen, K.R.,Rasper, D.,Ruzin, A.,Sawyer, W.S.,Shaul, J.,Shen, X.,Shia, S.,Steffek, M.,Subramanian, S.,Vo, J.,Wang, F.,Wartchow, C.,Uehara, T. Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis. J.Am.Chem.Soc., 142:4445-4455, 2020 Cited by PubMed: 32064871DOI: 10.1021/jacs.9b13530 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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