6P9R

E.coli LpxA in complex with UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc and Compound 6

6P9R の概要

• エントリーDOI: 10.2210/pdb6p9r/pdb
• 分子名称: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: acyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30584.35

構造登録者

Ma, X.,Shia, S.,Ornelas, E. (登録日: 2019-06-10, 公開日: 2020-03-11, 最終更新日: 2023-10-11)

• 主引用文献: Han, W.,Ma, X.,Balibar, C.J.,Baxter Rath, C.M.,Benton, B.,Bermingham, A.,Casey, F.,Chie-Leon, B.,Cho, M.K.,Frank, A.O.,Frommlet, A.,Ho, C.M.,Lee, P.S.,Li, M.,Lingel, A.,Ma, S.,Merritt, H.,Ornelas, E.,De Pascale, G.,Prathapam, R.,Prosen, K.R.,Rasper, D.,Ruzin, A.,Sawyer, W.S.,Shaul, J.,Shen, X.,Shia, S.,Steffek, M.,Subramanian, S.,Vo, J.,Wang, F.,Wartchow, C.,Uehara, T.; Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.; J.Am.Chem.Soc., 142:4445-4455, 2020; PubMed: 32064871; DOI: 10.1021/jacs.9b13530

実験手法

X-RAY DIFFRACTION (1.75 Å)