6P9L

Crystal structure of Mycobacterium tuberculosis KasA in complex with JFX

6P9L の概要

• エントリーDOI: 10.2210/pdb6p9l/pdb
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4-fluoro-N-(3-methyl-1H-indazol-5-yl)butane-1-sulfonamide, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: beta ketoacyl synthase i, lipid synthesis, fatty acid biosynthesis, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43842.61

構造登録者

Capodagli, G.C.,Neiditch, M.B. (登録日: 2019-06-10, 公開日: 2020-04-01, 最終更新日: 2023-10-11)

• 主引用文献: Inoyama, D.,Awasthi, D.,Capodagli, G.C.,Tsotetsi, K.,Sukheja, P.,Zimmerman, M.,Li, S.G.,Jadhav, R.,Russo, R.,Wang, X.,Grady, C.,Richmann, T.,Shrestha, R.,Li, L.,Ahn, Y.M.,Ho Liang, H.P.,Mina, M.,Park, S.,Perlin, D.S.,Connell, N.,Dartois, V.,Alland, D.,Neiditch, M.B.,Kumar, P.,Freundlich, J.S.; A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.; Cell Chem Biol, 27:560-, 2020; PubMed: 32197094; DOI: 10.1016/j.chembiol.2020.02.007

実験手法

X-RAY DIFFRACTION (2.305 Å)