6P9E

Crystal structure of IL-36gamma complexed to A-552

Summary for 6P9E

Entry DOI	10.2210/pdb6p9e/pdb
Descriptor	Interleukin-36 gamma, (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid (3 entities in total)
Functional Keywords	il-36, small molecule antagonist, cytokine
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	17514.95
Authors	Argiriadi, M.A.,Todorovic, T.,Su, Z.,Putman, B.,Kakavas, S.J.,Salte, K.M.,McDonald, H.A.,Wetter, J.B.,Paulsboe, S.E.,Sun, Q.,Gerstein, C.E.,Medina, L.,Sielaff, B.,Sadhukhan, R.,Stockmann, H.,Richardson, P.L.,Qiu, W.,Henry, R.F.,Herold, J.M.,Shotwell, J.B.,McGaraughty, S.P.,Honore, P.,Gopalakrishnan, S.M.,Sun, C.C.,Scott, V.E. (deposition date: 2019-06-10, release date: 2019-06-26, Last modification date: 2023-10-11)
Primary citation	Todorovic, V.,Su, Z.,Putman, C.B.,Kakavas, S.J.,Salte, K.M.,McDonald, H.A.,Wetter, J.B.,Paulsboe, S.E.,Sun, Q.,Gerstein, C.E.,Medina, L.,Sielaff, B.,Sadhukhan, R.,Stockmann, H.,Richardson, P.L.,Qiu, W.,Argiriadi, M.A.,Henry, R.F.,Herold, J.M.,Shotwell, J.B.,McGaraughty, S.P.,Honore, P.,Gopalakrishnan, S.M.,Sun, C.C.,Scott, V.E. Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9:9089-9089, 2019 Cited by PubMed: 31235749 DOI: 10.1038/s41598-019-45626-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation