6P9B

HIV-1 Protease multiple drug resistant mutant PRS5B with Amprenavir

6P9B の概要

• エントリーDOI: 10.2210/pdb6p9b/pdb
• 関連するPDBエントリー: 3NU3
• 分子名称: HIV-1 protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: protease, inhibitor, multiple mutant, hydrolase-hydrolase inhibitor, viral protein complex, hydrolase/hydrolase inhibitor, viral protein
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22326.62

構造登録者

Kneller, D.W.,Agniswamy, J.,Weber, I.T. (登録日: 2019-06-10, 公開日: 2020-04-15, 最終更新日: 2023-10-11)

• 主引用文献: Kneller, D.W.,Agniswamy, J.,Harrison, R.W.,Weber, I.T.; Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.; Febs J., 287:3235-3254, 2020; PubMed: 31920003; DOI: 10.1111/febs.15207

実験手法

X-RAY DIFFRACTION (1.75 Å)