6P8A

E.coli LpxD in complex with compound 8.1

6P8A の概要

• エントリーDOI: 10.2210/pdb6p8a/pdb
• 分子名称: UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase, MAGNESIUM ION, 2-[4,6-dimethyl-3-(1H-pyrrol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-[3-(morpholin-4-yl)propyl]acetamide, ... (5 entities in total)
• 機能のキーワード: lps synthesis, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 109527.95

構造登録者

Ma, X.,Shia, S. (登録日: 2019-06-06, 公開日: 2019-08-28, 最終更新日: 2023-10-11)

• 主引用文献: Ma, X.,Prathapam, R.,Wartchow, C.,Chie-Leon, B.,Ho, C.M.,De Vicente, J.,Han, W.,Li, M.,Lu, Y.,Ramurthy, S.,Shia, S.,Steffek, M.,Uehara, T.; Structural and Biological Basis of Small Molecule Inhibition ofEscherichia coliLpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis.; Acs Infect Dis., 6:1480-1489, 2020; PubMed: 31402665; DOI: 10.1021/acsinfecdis.9b00127

実験手法

X-RAY DIFFRACTION (1.8 Å)