6P6Z

HCV NS3/4A protease domain of genotype 4a with an extended linker in complex with glecaprevir

6P6Z の概要

• エントリーDOI: 10.2210/pdb6p6z/pdb
• 分子名称: Non-structural protein 4A,Serine protease NS3, ZINC ION, Glecaprevir, ... (4 entities in total)
• 機能のキーワード: hcv ns3/4a protease hcv protease domain glecaprevir, gle genotype 4a, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus genotype 4a (isolate ED43) (HCV); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22049.29

構造登録者

Timm, J.,Schiffer, C.A. (登録日: 2019-06-04, 公開日: 2020-06-10, 最終更新日: 2025-01-29)

• 主引用文献: Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A.; Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences; To Be Published,

実験手法

X-RAY DIFFRACTION (2.294 Å)