6P6Z
HCV NS3/4A protease domain of genotype 4a with an extended linker in complex with glecaprevir
6P6Z の概要
エントリーDOI | 10.2210/pdb6p6z/pdb |
分子名称 | Non-structural protein 4A,Serine protease NS3, ZINC ION, (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, ... (4 entities in total) |
機能のキーワード | hcv ns3/4a protease hcv protease domain glecaprevir, gle genotype 4a, viral protein, hydrolase |
由来する生物種 | Hepatitis C virus genotype 4a (isolate ED43) (HCV) 詳細 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 22049.29 |
構造登録者 | |
主引用文献 | Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A. Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.294 Å) |
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