6P6Q

HCV NS3/4A protease domain of genotype 1a3a chimera in complex with grazoprevir

6P6Q の概要

• エントリーDOI: 10.2210/pdb6p6q/pdb
• 分子名称: Non-structural protein 4A,Serine protease NS3, (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-di oxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadec ino[11,12-b]quinoxaline-8-carboxamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: hcv ns3/4a protease hcv protease domain grazoprevir, gzr genotype 1a3a chimera, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus genotype 1a (isolate 1) (HCV); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45648.10

構造登録者

Timm, J.,Schiffer, C.A. (登録日: 2019-06-04, 公開日: 2020-06-10, 最終更新日: 2023-10-11)

• 主引用文献: Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A.; Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences; To Be Published,

実験手法

X-RAY DIFFRACTION (3.5 Å)