6P6M

HCV NS3/4A protease domain of genotype 1a C159 in complex with glecaprevir

6P6M の概要

• エントリーDOI: 10.2210/pdb6p6m/pdb
• 分子名称: Non-structural protein 4A, Serine protease NS3, (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: hcv ns3/4a protease hcv protease domain glecaprevir, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus genotype 1a (isolate 1) (HCV); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22651.25

構造登録者

Timm, J.,Schiffer, C.A. (登録日: 2019-06-04, 公開日: 2020-06-10, 最終更新日: 2023-10-11)

• 主引用文献: Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A.; HCV NS3/4A protease domain of genotype 1a in complex with glecaprevir; To Be Published,

実験手法

X-RAY DIFFRACTION (2.201 Å)