6P5W

Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide

Summary for 6P5W

Entry DOI	10.2210/pdb6p5w/pdb
Descriptor	Lysozyme,DCN1-like protein 1 chimera, 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide (3 entities in total)
Functional Keywords	e3 ligase, hydrolase, ligase
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	1
Total formula weight	44757.88
Authors	Guy, R.K.,Kim, H.S.,Hammill, J.T.,Scott, D.C.,Schulman, B.A. (deposition date: 2019-05-31, release date: 2019-09-11, Last modification date: 2023-10-11)
Primary citation	Kim, H.S.,Hammill, J.T.,Scott, D.C.,Chen, Y.,Min, J.,Rector, J.,Singh, B.,Schulman, B.A.,Guy, R.K. Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. J.Med.Chem., 62:8429-8442, 2019 Cited by PubMed: 31465221 DOI: 10.1021/acs.jmedchem.9b00410 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation