6P5W
Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
Summary for 6P5W
Entry DOI | 10.2210/pdb6p5w/pdb |
Descriptor | Lysozyme,DCN1-like protein 1 chimera, 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide (3 entities in total) |
Functional Keywords | e3 ligase, hydrolase, ligase |
Biological source | Enterobacteria phage T4 More |
Total number of polymer chains | 1 |
Total formula weight | 44757.88 |
Authors | Guy, R.K.,Kim, H.S.,Hammill, J.T.,Scott, D.C.,Schulman, B.A. (deposition date: 2019-05-31, release date: 2019-09-11, Last modification date: 2023-10-11) |
Primary citation | Kim, H.S.,Hammill, J.T.,Scott, D.C.,Chen, Y.,Min, J.,Rector, J.,Singh, B.,Schulman, B.A.,Guy, R.K. Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. J.Med.Chem., 62:8429-8442, 2019 Cited by PubMed: 31465221DOI: 10.1021/acs.jmedchem.9b00410 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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