6OZ6

Crystal structure of MraY bound to 3'-hydroxymureidomycin A

6OZ6 の概要

• エントリーDOI: 10.2210/pdb6oz6/pdb
• 分子名称: MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (2~{S})-2-[[(2~{S})-1-[[(2~{S},3~{S})-3-[[(2~{S})-2-azanyl-3-(3-hydroxyphenyl)propanoyl]-methyl-amino]-1-[[(~{Z})-[(3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-ylidene]methyl]amino]-1-oxidanylidene-butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]carbamoylamino]-3-(3-hydroxyphenyl)propanoic acid (3 entities in total)
• 機能のキーワード: peptidoglycan biosynthesis, antibiotic target, integral membrane enzyme, translocase, membrane protein, membrane protein-transferase complex, membrane protein/transferase
• 由来する生物種: Lama glama; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 226620.04

構造登録者

Mashalidis, E.H.,Lee, S.Y. (登録日: 2019-05-15, 公開日: 2019-07-10, 最終更新日: 2023-10-11)

• 主引用文献: Mashalidis, E.H.,Kaeser, B.,Terasawa, Y.,Katsuyama, A.,Kwon, D.Y.,Lee, K.,Hong, J.,Ichikawa, S.,Lee, S.Y.; Chemical logic of MraY inhibition by antibacterial nucleoside natural products.; Nat Commun, 10:2917-2917, 2019; PubMed: 31266949; DOI: 10.1038/s41467-019-10957-9

実験手法

X-RAY DIFFRACTION (3.7 Å)