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6OYR

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-002

Summary for 6OYR
Entry DOI10.2210/pdb6oyr/pdb
DescriptorProtease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-1-(3-fluorophenyl)-3-hydroxy-4-[(2-methylpropyl)({2-[(propan-2-yl)amino]-1,3-benzoxazol-6-yl}sulfonyl)amino]butan-2-yl}carbamate (3 entities in total)
Functional Keywordsinhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains1
Total formula weight11505.56
Authors
Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2019-05-15, release date: 2020-05-20, Last modification date: 2023-10-11)
Primary citationBulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Das, D.,Aoki, M.,Davis, D.A.,Rao, K.V.,Nyalapatla, P.R.,Ghosh, A.K.,Mitsuya, H.
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
Sci Rep, 10:10664-10664, 2020
Cited by
PubMed: 32606378
DOI: 10.1038/s41598-020-65993-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

217705

數據於2024-03-27公開中

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