6OXX
HIV-1 Protease NL4-3 WT in Complex with LR2-18
Summary for 6OXX
Entry DOI | 10.2210/pdb6oxx/pdb |
Descriptor | Protease NL4-3, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate (3 entities in total) |
Functional Keywords | hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22256.37 |
Authors | Lockbaum, G.J.,Rusere, L.N.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. (deposition date: 2019-05-14, release date: 2019-08-21, Last modification date: 2023-10-11) |
Primary citation | Rusere, L.N.,Lockbaum, G.J.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,Yilmaz, N.K.,Schiffer, C.A.,Ali, A. HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope. J.Med.Chem., 62:8062-8079, 2019 Cited by PubMed: 31386368DOI: 10.1021/acs.jmedchem.9b00838 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.962 Å) |
Structure validation
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