6OW2

X-ray Structure of Polypeptide Deformylase

Summary for 6OW2

Entry DOI	10.2210/pdb6ow2/pdb
Descriptor	Peptide deformylase, NICKEL (II) ION, (2R)-2-(cyclopentylmethyl)-N'-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methylpyrimidin-4-yl}-3-[hydroxy(hydroxymethyl)amino]propanehydrazide, ... (4 entities in total)
Functional Keywords	inhibitor, complex, metal protein, enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Streptococcus pneumoniae
Total number of polymer chains	1
Total formula weight	23130.11
Authors	Campobasso, N.,Spletstoser, J.,Ward, P. (deposition date: 2019-05-09, release date: 2019-06-26, Last modification date: 2024-03-13)
Primary citation	Spletstoser, J.T.,Dreabit, J.,Knox, A.N.,Benowitz, A.,Campobasso, N.,Ward, P.,Cui, G.,Lewandowski, T.,McCloskey, L.,Aubart, K.M. Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. Bioorg.Med.Chem.Lett., 29:2410-2414, 2019 Cited by PubMed: 31160176 DOI: 10.1016/j.bmcl.2019.05.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation