6OW2

X-ray Structure of Polypeptide Deformylase

6OW2 の概要

• エントリーDOI: 10.2210/pdb6ow2/pdb
• 分子名称: Peptide deformylase, NICKEL (II) ION, (2R)-2-(cyclopentylmethyl)-N'-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methylpyrimidin-4-yl}-3-[hydroxy(hydroxymethyl)amino]propanehydrazide, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, metal protein, enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Streptococcus pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23130.11

構造登録者

Campobasso, N.,Spletstoser, J.,Ward, P. (登録日: 2019-05-09, 公開日: 2019-06-26, 最終更新日: 2024-03-13)

• 主引用文献: Spletstoser, J.T.,Dreabit, J.,Knox, A.N.,Benowitz, A.,Campobasso, N.,Ward, P.,Cui, G.,Lewandowski, T.,McCloskey, L.,Aubart, K.M.; Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.; Bioorg.Med.Chem.Lett., 29:2410-2414, 2019; PubMed: 31160176; DOI: 10.1016/j.bmcl.2019.05.028

実験手法

X-RAY DIFFRACTION (1.7 Å)