6ORO

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP

6ORO の概要

• エントリーDOI: 10.2210/pdb6oro/pdb
• EMDBエントリー: 20176
• 分子名称: RC1 variant of HIV-1 Env glycoprotein gp41, RC1 variant of HIV-1 Env glycoprotein gp120, Ab874NHP antibody Fab heavy chain, ... (9 entities in total)
• 機能のキーワード: hiv-1 broadly-neutralizing antibody, env trimer structure, v3-glycan patch, cryo-em, rc1, immunogen design, antiviral protein-immune system complex, antiviral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 388288.09

構造登録者

Abernathy, M.E.,Gristick, H.B.,Bjorkman, P.J. (登録日: 2019-04-30, 公開日: 2019-06-12, 最終更新日: 2020-07-29)

• 主引用文献: Escolano, A.,Gristick, H.B.,Abernathy, M.E.,Merkenschlager, J.,Gautam, R.,Oliveira, T.Y.,Pai, J.,West Jr., A.P.,Barnes, C.O.,Cohen, A.A.,Wang, H.,Golijanin, J.,Yost, D.,Keeffe, J.R.,Wang, Z.,Zhao, P.,Yao, K.H.,Bauer, J.,Nogueira, L.,Gao, H.,Voll, A.V.,Montefiori, D.C.,Seaman, M.S.,Gazumyan, A.,Silva, M.,McGuire, A.T.,Stamatatos, L.,Irvine, D.J.,Wells, L.,Martin, M.A.,Bjorkman, P.J.,Nussenzweig, M.C.; Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.; Nature, 570:468-473, 2019; PubMed: 31142836; DOI: 10.1038/s41586-019-1250-z

実験手法

ELECTRON MICROSCOPY (3.9 Å)