6OPT

HIV-1 Protease NL4-3 V82F, I84V Mutant in complex with darunavir

6OPT の概要

• エントリーDOI: 10.2210/pdb6opt/pdb
• 分子名称: Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22471.49

構造登録者

Lockbaum, G.J.,Henes, M.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A. (登録日: 2019-04-25, 公開日: 2019-09-04, 最終更新日: 2023-10-11)

• 主引用文献: Henes, M.,Lockbaum, G.J.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Lee, S.K.,Spielvogel, E.,Zhou, S.,Swanstrom, R.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A.; Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.; Acs Chem.Biol., 14:2441-2452, 2019; PubMed: 31361460; DOI: 10.1021/acschembio.9b00370

実験手法

X-RAY DIFFRACTION (1.96 Å)